Aldebaran M . Hofer and Konstantinos Lefkimmiatis ' ' Third Messengers ' ' ? Extracellular Calcium and cAMP : Second Messengers as
نویسندگان
چکیده
Physiol. Soc.. ESSN: 1548-9221. Visit our website at http://www.the-aps.org/. Sci./Am. American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. © 2007 Int. Union Physiol. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological Science) publishes brief review articles on major Physiology by gest on N ovem er 7, 2016 http://physioline.physiology.org/ D ow nladed fom
منابع مشابه
Export of cAMP from Stimulated Cells
touched by Ca2+ and cAMP is the extracellular space. It has long been known that intracellular signaling events are associated with changes in second messenger concentrations outside the cell. Can these fluctuations be regarded as “signals” in their own right? This article will address how cAMP and Ca2+ move across the cell membrane, the potential mechanisms for sensing these extracellular chan...
متن کاملTermination and activation of store-operated cyclic AMP production
Diverse pathophysiological processes (e.g. obesity, lifespan determination, addiction and male fertility) have been linked to the expression of specific isoforms of the adenylyl cyclases (AC1-AC10), the enzymes that generate cyclic AMP (cAMP). Our laboratory recently discovered a new mode of cAMP production, prominent in certain cell types, that is stimulated by any manoeuvre causing reduction ...
متن کامل“cAMP Sponge”: A Buffer for Cyclic Adenosine 3′, 5′-Monophosphate
BACKGROUND While intracellular buffers are widely used to study calcium signaling, no such tool exists for the other major second messenger, cyclic AMP (cAMP). METHODS/PRINCIPAL FINDINGS Here we describe a genetically encoded buffer for cAMP based on the high-affinity cAMP-binding carboxy-terminus of the regulatory subunit RIbeta of protein kinase A (PKA). Addition of targeting sequences perm...
متن کاملCross-Talk between Signaling Pathways Can Generate Robust Oscillations in Calcium and cAMP
BACKGROUND To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making. A key feature of signal transduction is the generation of only a few intracellular messengers by many extracellular stimuli. METHODOLOGY/PRINCIPAL FINDINGS Here we model molecular cross-talk between two classic second messengers, cyclic...
متن کاملThe -3 fatty acid eicosapentaenoic acid elicits cAMP generation in colonic epithelial cells via a “store-operated” mechanism
Roy J, Lefkimmiatis K, Moyer MP, Curci S, Hofer AM. The -3 fatty acid eicosapentaenoic acid elicits cAMP generation in colonic epithelial cells via a “store-operated” mechanism. Am J Physiol Gastrointest Liver Physiol 299: G715–G722, 2010. First published June 24, 2010; doi:10.1152/ajpgi.00028.2010.—Eicosapentaenoic acid (EPA) is an -3 polyunsaturated fatty acid abundant in fish oil that exerts...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007